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PREA-SB injection is a combination of two drugs called cefoperazone and sulbactam anhydrous. This drug is used to treat bacterial infections in the respiratory tract, urinary tract, blood infection, meningitis, skin, abdominal, bone, joint infections, or sexually transmitted diseases. 

Cefoperazone belongs to the class of antibiotics known as cephalosporins. It is effective against a wide range of bacteria by inhibiting the synthesis of their cell walls. Cefoperazone is particularly effective against gram-negative bacteria and some gram-positive bacteria. 

Sulbactam anhydrous is a substance that helps antibiotics work better against certain bacteria. It does this by stopping enzymes called beta-lactamases from breaking down the antibiotics. When these enzymes are blocked, the antibiotic cefoperazone can fight the bacteria more effectively.

Cefoperazone and sulbactam anhydrous, when used together, create a synergistic effect. This means that their combined action is more powerful than when either drug is used alone. This combination is particularly helpful in treating infections caused by bacteria that are resistant to multiple drugs or in situations where resistance is likely to occur. The dosage and duration of treatment will depend on the specific infection being treated, the severity of the infection, and the patient’s individual factors such as age and overall health.

How to use 

 Here is some general information about the administration of injectable medications:

Medical supervision: Cefoperazone and sulbactam anhydrous injections should be administered under the supervision of a healthcare professional, usually in a hospital or clinical setting. They will determine the appropriate dosage and frequency of administration based on your condition.

Sterile technique:  It’s important to keep the area clean. The healthcare worker will use sterile tools, like syringes and needles, and practice good hand hygiene and aseptic methods to reduce the risk of infection.

Injection site: The injection is typically given directly into a vein (intravenous or IV) or into a muscle (intramuscular or IM). The specific route of administration will depend on the healthcare professional’s judgment and the characteristics of the medication.

Monitoring and follow-up: During treatment with cefoperazone and sulbactam anhydrous injection, your healthcare professional will monitor your response to the medication and may perform tests to ensure its effectiveness. It is crucial to attend all follow-up appointments and report any concerns or side effects to your healthcare provider.

Uses of  cefoperazone and sulbactam anhydrous Injection

Cefoperazone and sulbactam anhydrous is used to treat all kind if bacterial infections. The combination of these drugs is very effective you will get relief from your problems in just 2 to 3 days. Here are the uses of this injection:

  • Respiratory tract infection
  • Urinary tract infection
  • Blood infection
  • Meningitis (inflammation of the fluid and membranes surrounding the brain and spinal cord)
  • Sexually Transmitted Disease (Gonorrhoea & Chlamydia)
  • Skin Infection
  • Joint Infection
  • Abdominal infection

Side effects

 cefoperazone and sulbactam anhydrous injection is used to treat a variety of bacterial infections. However, like other drugs, it may cause some side effects. Here are the few side effects:

  • Low blood platelets
  • Coagulation disorder
  • Fluctuation in white blood cell count
  • Anaemia (low count of red blood cells)
  • Diarrhoea
  • Allergic reaction
  • Abnormal liver function tests
  • Difficulty in breathing
  • Anaphylactic shock
  • Anaphylactic reaction
  • Hypersensitivity

If you experience any of these side effects so please get in touch with your doctor.


Precautions to be taken when using cefoperazone and sulbactam anhydrous include:

Allergies: Inform your healthcare provider if you are allergic to cefoperazone, sulbactam, or any other cephalosporin antibiotics.

Medical History: Provide your medical history with your doctor. This information will help your doctor with the perfect dosage and monitor your health condition during the treatment.

Drug Interactions: Inform your doctor about all the medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins.

Side Effects: Cefoperazone and sulbactam may cause side effects such as diarrhoea, nausea, vomiting, headache, or rash. If these side effects persist or worsen, contact your healthcare provider.

Healthy diet: Follow a healthy diet while taking the treatment of this injection.

Additional information

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